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KMID : 0545120050150030640
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Journal of Microbiology and Biotechnology
2005 Volume.15 No. 3 p.640 ~ p.645
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The Role of a Second Protein (DesⅧ) in Glycosylation for the Biosynthesis of Hybrid Macrolide Antibiotics in Streptomyces venezuelae
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Hong JS
Kim WS/Lee SK/Koh HS/Park HS/Park SJ/Kim YS/Yoon YJ
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Abstract
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The function of the desVIII gene in the pikromycin producer Streptomyces venezuelae was characterized by gene deletion and complementation analysis. In addition to the DesVII glycosyltransferase, the desVIII gene that has previously been suggested to be required for the incorporation of endogenous deoxysugar, TDP-D-desosamine, into the aglycone of pikromycin is also required for the transfer of exogenous deoxysugars, TDP-D-quinovose and TDP-D-olivose.
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